Immediately after the final dose of an earlier treatment, a patient has \(40\,\text{mg}\) of a medication in the body at day \(0\). The patient now takes \(5\,\text{mg}\) once daily. Before each new dose, the body eliminates \(20\%\) of the medication present.
a) Find the amount immediately after the dose on days \(1\) and \(2\).
b) Show that the amount decreases over time despite the daily dose, and find the value to which it stabilizes.
c) How would the limiting amount change if the body eliminated \(25\%\) each day instead of \(20\%\)?
Hints
- Compare the amount removed during a day with the fixed amount added afterward.
- To prove the direction of change, express \(A_{n+1}-A_n\) in terms of \(A_n\).
- Compare each term with the equilibrium value to determine whether the sequence can cross it.
- In part c, change only the retention factor in the equilibrium equation.
Solution
1. The recurrence is \(A_{n+1}=0.8A_n+5\), with \(A_0=40\). Thus \(A_1=0.8\cdot40+5=37\,\text{mg}\) and \(A_2=0.8\cdot37+5=34.6\,\text{mg}\).
2. The daily change is \(A_{n+1}-A_n=5-0.2A_n\), which is negative whenever \(A_n>25\).
3. Also, \(A_{n+1}-25=0.8(A_n-25)\). Since \(A_0>25\), every term remains above \(25\), so the change stays negative while the distance from \(25\) is multiplied by \(0.8\). Therefore, the sequence decreases toward \(25\,\text{mg}\).
4. With a \(25\%\) daily elimination, the limit satisfies \(L=0.75L+5\), giving \(L=20\,\text{mg}\). The limiting amount decreases by \(5\,\text{mg}\).
Answer
a) Day \(1\): \(37\,\text{mg}\); day \(2\): \(34.6\,\text{mg}\)
b) \(A_{n+1}-A_n=5-0.2A_n<0\) while \(A_n>25\), and \(A_{n+1}-25=0.8(A_n-25)>0\). Thus the amount decreases while staying above \(25\,\text{mg}\), and it approaches \(25\,\text{mg}\).
c) The limiting amount would decrease to \(20\,\text{mg}\).