After an injection, the concentration of a medication in the blood is modeled by
\(f(t)=10te^{-0.2t}\),
where \(t\geq0\) is measured in hours and \(f(t)\) is measured in \(\text{mg/L}\).
a) Find the time \(t_{\max}\) when the concentration is greatest.
b) Find the maximum concentration, rounded to two decimal places.
c) Verify that \(F(t)=-50(t+5)e^{-0.2t}\) is an antiderivative of \(f\).
d) Find the average concentration during the first \(20\) hours.

Hints
- Use the product rule and chain rule to differentiate \(f\).
- A maximum can occur where the first derivative changes from positive to negative.
- To verify an antiderivative, differentiate it.
- Use the average-value formula for a function on an interval.
Solution
1. By the product and chain rules, \(f'(t)=(10-2t)e^{-0.2t}\). Since the exponential factor is positive, \(f'(t)=0\) when \(10-2t=0\), so \(t_{\max}=5\) hours. The derivative changes from positive to negative there.
2. \(f(5)=50e^{-1}\approx 18.39\,\text{mg/L}\).
3. Differentiate \(F\): \(F'(t)=-50\left[e^{-0.2t}-0.2(t+5)e^{-0.2t}\right]=10te^{-0.2t}=f(t)\). Therefore, \(F\) is an antiderivative of \(f\).
4. The average value on \([0,20]\) is \(\frac{1}{20}\int_0^{20}f(t)\,dt=\frac{F(20)-F(0)}{20}\). Since \(F(20)=-1250e^{-4}\approx-22.89\) and \(F(0)=-250\), the average is \(\frac{-22.89+250}{20}\approx 11.36\,\text{mg/L}\).
Answer
a) \(t_{\max}=5\) hours
b) About \(18.39\,\text{mg/L}\)
c) \(F'(t)=f(t)\), so \(F\) is an antiderivative of \(f\)
d) About \(11.36\,\text{mg/L}\)